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Mutant Enemy Productions, also known as Mutant Enemy Etc., and simply Mutant Enemy, is a production company formed in 1996 by Joss Whedon. It first produced Buffy the Vampire Slayer for 20th Century Fox Television, then the spin-off Angel, followed by other works such as Firefly, Dollhouse, Dr. Horrible's Sing-Along Blog, and Cabin in the Words.

From 2013-2020, it produced Agents of S.H.I.E.L.D. with Marvel Television and ABC Studios. Various actors and crew from past Enemy Mutant works have gone onto participate in Agents.

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