Wise and her boyfriend, Bennie Pollack, wound up recruited by S.H.I.E.L.D. after they stole a Chitauri gun left behind from the Battle of New York. She worked as Felix Blake's assistant. Since then, S.H.I.E.L.D. was taken down from the inside by double agents of Hydra in Captain America: The Winter Soldier and the Agents of S.H.I.E.L.D. episode, "Turn, Turn, Turn", leaving Wise's status unknown.
Wise's allies consist or consisted of Pollack, Jasper Sitwell, and Blake.